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KMID : 0602819960020010046
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Korean Journal of Bronchoesophagology
1996 Volume.2 No. 1 p.46 ~ p.56
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Chondrogenic Activity of Vascularized Perichondrial Flap for Rabbit Tracheal
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김은서
최은창/김영호/홍원표/김영덕
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Abstract
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Perichondrium is generally used for reconstruction of airway and successful regeneration
of cartilage framework using perichondrium are reported by several authors. It has many
advantages for airway reconstruction. It can maintain the stable framework and it has highter
flexibility so it's easy to design according to the shape of defects. it resist strongly against
infection process. Its arirtightness and rapid mucosalization enables to predict good
postoperative recovery and results.
To investigate the differences in cartilage regeneration between avascular and vascularized
perichondrial flap, this study was designed with vascularized flaps composed of vascularized
perichondrium and central auricular artery and vein. Morphologic study was performed to
determine the fate of the grafted perichondrium at regular intervals using light microscopy
with H & E stain.
Chondrogenic potential and formation of cartilaginous plate of experimental group was
superior than in the control group. Grafted perichondrium was fed by consistent feeding
vessel. At 6 weeks, the regenerated cartilage could hardly be distinguished form the normal
cartilage framework but in control group, regenerated cartilaginous tissue was generally
immature in same period.
In concludion, this study indicated that consistent vasculature to grafed tissue is the essential
factor for successful reconstruction of cartilaginous framework.
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